A Comparative View of Reported Adverse Effects of Statins in Social Media, Regulatory Data, Drug Information Databases and Systematic Reviews

Susan Golder (), Karen Smith (), Karen O’Connor (), Robert Gross (), Sean Hennessy () and Graciela Gonzalez-Hernandez ()
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Karen Smith: Regis University School of Pharmacy
Karen O’Connor: University of Pennsylvania
Robert Gross: University of Pennsylvania
Sean Hennessy: University of Pennsylvania
Graciela Gonzalez-Hernandez: University of Pennsylvania

Drug Safety, 2021, vol. 44, issue 2, No 3, 167-179

Abstract: Abstract Introduction There are few studies assessing how data on adverse drug events from consumers on social media compare with other sources. Aim The aim of this study was to assess the consistency of adverse event data of statin medications from social media as compared with other sources. Methods We collected data on the adverse events of statins from Twitter, the US FDA Adverse Event Reporting System (FAERS), the UK Medicines and Healthcare products Regulatory Agency (MHRA), drug information databases (DIDs) and systematic reviews. We manually annotated 12,649 tweets collected between June 2013 and August 2018. We collected 45,447 reports from FAERS, 10,415 from MHRA, identified 17 systematic reviews with relevant data and extracted data from Facts and Comparisons® and Clinical Pharmacology®. We compared the proportion, relative frequencies and rank of each category of adverse event from each source using MedDRA® primary System Organ Class codes. Results Compared with other sources, patients on social media are proportionally far more likely to complain about musculoskeletal symptoms than other adverse events. Most adverse events showed a high level of agreement between Twitter and regulatory data. DIDs tend to demonstrate similar patterns but not as strongly. Systematic reviews tend to examine pre-specified adverse events or those reported by trial investigators. Conclusions Combining the data from multiple sources, albeit challenging, may provide a broader safety profile of any medication. Systematically collected social media reports may be able to contribute information on the most pertinent adverse effects to patients.

Date: 2021
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DOI: 10.1007/s40264-020-00998-1

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