Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review

Hao Niu, Edmond Atallah, Ismael Alvarez-Alvarez, Inmaculada Medina-Caliz, Guruprasad P. Aithal, Cigdem Arikan, Raul J. Andrade and M. Isabel Lucena ()
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Hao Niu: Universidad de Málaga
Edmond Atallah: University of Nottingham
Ismael Alvarez-Alvarez: Universidad de Málaga
Inmaculada Medina-Caliz: Universidad de Málaga
Guruprasad P. Aithal: University of Nottingham
Cigdem Arikan: Koç University
Raul J. Andrade: Universidad de Málaga
M. Isabel Lucena: Universidad de Málaga

Drug Safety, 2022, vol. 45, issue 11, No 1, 1329-1348

Abstract: Abstract Introduction Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. Methods We included original articles conducted in a paediatric population (

Date: 2022
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DOI: 10.1007/s40264-022-01224-w

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