Paracetamol Dosing Errors in People Aged 12 Years and Over: An Analysis of Over 14,000 Cases Reported to an Australian Poisons Information Centre

Annabelle S. Chidiac (), Nicholas A. Buckley, Firouzeh Noghrehchi and Rose Cairns
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Annabelle S. Chidiac: The University of Sydney
Nicholas A. Buckley: The University of Sydney
Firouzeh Noghrehchi: The University of Sydney
Rose Cairns: The University of Sydney

Drug Safety, 2024, vol. 47, issue 12, No 9, 1293-1306

Abstract: Abstract Introduction Paracetamol dosing errors can cause acute liver injury, with potentially toxic doses only slightly above the therapeutic range. This study aimed to characterise unintentional paracetamol overdose reported to an Australian poisons centre, including time trends, demographics, types of dosing errors, and outcomes. Methods Records regarding paracetamol dosing errors for individuals aged ≥12 years were extracted from the New South Wales Poisons Information Centre database, January 2017 to June 2023. Data from 2021 underwent an in-depth screening of free text case notes to examine: dose, duration, products involved, reasons for ingestion and outcomes including hospitalisation, treatment, liver transplantations and deaths. Where possible, complete outcome data were obtained from medical records of New South Wales hospitalised cases in 2021. Results There were 14,380 exposures due to paracetamol dosing errors (predominantly self-administered, median age 43 years, 62.6% female), with an average yearly increase of 2.5% (95% CI 1.6–3.8%; p

Date: 2024
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DOI: 10.1007/s40264-024-01472-y

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