Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice

Maria Rayane Correia Oliveira, Maria Gabriely Lima Silva, Isabel Sousa Alcântara, Jaime Ribeiro Filho, Cícera Datiane de Morais Oliveira Tintino, Francisco Ernani Alves Magalhães, Anita Oliveira Brito Pereira Bezerra Martins, Renata Torres Pessoa, Antonia Eliene Duarte, José Galberto Martins Costa, Sidney Gonçalo Lima, Henrique Douglas Melo Coutinho (), Raffaele Capasso () and Irwin Rose Alencar Menezes ()
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Maria Rayane Correia Oliveira: Regional University of Cariri-URCA, Brazil
Maria Gabriely Lima Silva: Regional University of Cariri-URCA, Brazil
Isabel Sousa Alcântara: Regional University of Cariri-URCA, Brazil
Jaime Ribeiro Filho: Regional University of Cariri-URCA, Brazil
Cícera Datiane de Morais Oliveira Tintino: Federal University of Pernambuco-UFPE
Francisco Ernani Alves Magalhães: State University of Ceará, Center of Education, Sciences and Technology of the Inhamuns Region-CECITEC
Anita Oliveira Brito Pereira Bezerra Martins: Regional University of Cariri-URCA, Brazil
Renata Torres Pessoa: Regional University of Cariri-URCA, Brazil
Antonia Eliene Duarte: Center for Biological and Health Sciences-CCBS
José Galberto Martins Costa: Regional University of Cariri-URCA, Brazil
Sidney Gonçalo Lima: Federal University of Piauí-UFPI, Brazil
Henrique Douglas Melo Coutinho: Regional University of Cariri-URCA, Brazil
Raffaele Capasso: University of Naples Federico II
Irwin Rose Alencar Menezes: Regional University of Cariri-URCA, Brazil

Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, 2021, vol. 23, issue 10, No 32, 14958-14981

Abstract: Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.

Keywords: Essential oil; Lantana montevidensis; Anti-inflammatory activity; Antinociceptive activity (search for similar items in EconPapers)
Date: 2021
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DOI: 10.1007/s10668-021-01281-8

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