Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue

L. R. Yeganyan, R. E. Muradyan, F. H. Arsenyan, G. K. Bazikyan and S. N. Ayrapetyan ()
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L. R. Yeganyan: Life Sciences International Postgraduate Educational Center
R. E. Muradyan: NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO
F. H. Arsenyan: NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO
G. K. Bazikyan: National Center of Oncology
S. N. Ayrapetyan: Life Sciences International Postgraduate Educational Center

Environment Systems and Decisions, 2012, vol. 32, issue 2, 236-241

Abstract: Abstract There are many data about the extremely low-frequency electromagnetic fields (ELF-EMF) therapeutic use, especially in the field of oncology. Recent data suggest that 4 Hz EMF having dehydration effect on tissues has a pronounced antitumor activity on sarcoma-180 in mice. It was shown that 4 Hz EMF have pronounced effects on physicochemical properties of water and water solution. Therefore, the aim of the present work was the comparative study of the modulation effect of ELF-EMF on cisplatin-induced changes cell hydration and number of ouabain receptors in membrane of sarcoma-180 tumor tissues. Tissue hydration was measured as wet weight/dry weight and expressed as a water content of g/g in dry weight. The number of 3H-ouabain receptors in membrane was counted by isotope scintillation counter. In conclusion, ELF-EMF can be a possible tool for stimulation of cisPt antitumor effect.

Keywords: Electromagnetic fields; Cancer; Cisplatin (search for similar items in EconPapers)
Date: 2012
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DOI: 10.1007/s10669-011-9378-x

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