Development of community of practice to support quantitative risk assessment for synthetic biology products: contaminant bioremediation and invasive carp control as cases

Benjamin D. Trump, Christy Foran, Taylor Rycroft, Matthew D. Wood (), Nirzwan Bandolin, Mariana Cains, Timothy Cary, Fiona Crocker, Nicholas A. Friedenberg, Patrick Gurian, Kerry Hamilton, Jan Jeffrey Hoover, Corey Meyer, Kaytee Pokrzywinski, Ryan Ritterson, Paul Schulte, Christopher Warner, Edward Perkins and Igor Linkov ()
Additional contact information
Benjamin D. Trump: ORISE
Christy Foran: US Army Corps of Engineers, Engineer Research and Development Center
Taylor Rycroft: US Army Corps of Engineers, Engineer Research and Development Center
Matthew D. Wood: US Army Corps of Engineers, Engineer Research and Development Center
Nirzwan Bandolin: Office of the Secretary of Defense
Mariana Cains: Indiana University Bloomington
Timothy Cary: US Army Corps of Engineers, Engineer Research and Development Center
Fiona Crocker: US Army Corps of Engineers, Engineer Research and Development Center
Nicholas A. Friedenberg: Applied Biomathematics
Patrick Gurian: Drexel University
Kerry Hamilton: Arizona State University
Jan Jeffrey Hoover: US Army Corps of Engineers, Engineer Research and Development Center
Corey Meyer: Gryphon Scientific, LLC
Kaytee Pokrzywinski: US Army Corps of Engineers, Engineer Research and Development Center
Ryan Ritterson: Gryphon Scientific, LLC
Paul Schulte: National Institute for Occupational Safety and Health
Christopher Warner: US Army Corps of Engineers, Engineer Research and Development Center
Edward Perkins: US Army Corps of Engineers, Engineer Research and Development Center
Igor Linkov: US Army Corps of Engineers, Engineer Research and Development Center

Environment Systems and Decisions, 2018, vol. 38, issue 4, 517-527

Abstract: Abstract Synthetic biology has the potential for a broad array of applications. However, realization of this potential is challenged by the paucity of relevant data for conventional risk assessment protocols, a limitation due to to the relative nascence of the field, as well as the poorly characterized and prioritized hazard, exposure, and dose–response considerations associated with the development and use of synthetic biology-derived organisms. Where quantitative risk assessment approaches are necessarily to fulfill regulatory requirements for review of products containing genetically modified organisms, this paper reviews one potential avenue for early-stage quantitative risk assessment for biosafety considerations of synthetic biology organism deployment into the environment. Building from discussion from a March 2018 US Army Engineer Research and Development Center workshop on developing such quantitative risk assessment for synthetic biology, this paper reviews the findings and discussion of workshop participants. This paper concludes that, while synthetic biology risk assessment and governance will continue to refine and develop in the coming years, a quantitative framework that builds from existing practice is one potentially beneficial option for risk assessors that must contend with the technology’s limited hazard characterization or exposure assessment considerations in the near term.

Keywords: Synthetic biology; Risk assessment; Technology governance (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (1)

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DOI: 10.1007/s10669-018-9710-9

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