Internal validation of models with several interventions

Afschin Gandjour () and Amiram Gafni

The European Journal of Health Economics, 2013, vol. 14, issue 6, 909 pages

Abstract: In cost-effectiveness analyses, models are used typically to synthesize the best available data and/or extrapolate beyond clinical trial data. Ideally, models should be validated both internally and externally. The purpose of this paper is to suggest a test for internal validation of models where several interventions for the same clinical indication are compared. To the best of our knowledge, such a specific test does not yet exist. There are four versions of the test, which consider the relationship between incremental downstream costs and effects in the case of a single or several endpoints. We apply two versions of the validation test to published cost-effectiveness analyses of physical activity programs and demonstrate internal validity of the model in one study and lack of internal validity of the model in the other study. Copyright Springer-Verlag Berlin Heidelberg 2013

Keywords: Cost-effectiveness analysis; Decision model; Validation; I1 (search for similar items in EconPapers)
Date: 2013
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DOI: 10.1007/s10198-012-0434-3

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