Economic evaluations of implantable cardioverter defibrillators: a systematic review

Lidia García-Pérez (), Pilar Pinilla-Domínguez, Antonio García-Quintana, Eduardo Caballero-Dorta, F. García-García, Renata Linertová and Iñaki Imaz-Iglesia

The European Journal of Health Economics, 2015, vol. 16, issue 8, 879-893

Abstract: The aim of this paper was to review the cost-effectiveness studies of implantable cardioverter defibrillators (ICD) for primary or secondary prevention of sudden cardiac death (SCD). A systematic review of the literature published in English or Spanish was performed by electronically searching MEDLINE and MEDLINE in process, EMBASE, NHS-EED, and EconLit. Some keywords were implantable cardioverter defibrillator, heart failure, heart arrest, myocardial infarction, arrhythmias, syncope, sudden death. Selection criteria were the following: (1) full economic evaluations published after 1995, model-based studies or alongside clinical trials (2) that explored the cost-effectiveness of ICD with or without associated treatment compared with placebo or best medical treatment, (3) in adult patients for primary or secondary prevention of SCD because of ventricular arrhythmias. Studies that fulfilled these criteria were reviewed and data were extracted by two reviewers. The methodological quality of the studies was assessed and a narrative synthesis was prepared. In total, 24 studies were included: seven studies on secondary prevention and 18 studies on primary prevention. Seven studies were performed in Europe. For secondary prevention, the results showed that the ICD is considered cost-effective in patients with more risk. For primary prevention, the cost-effectiveness of ICD has been widely studied, but uncertainty about its cost-effectiveness remains. The cost-effectiveness ratios vary between studies depending on the patient characteristics, methodology, perspective, and national settings. Among the European studies, the conclusions are varied, where the ICD is considered cost-effective or not dependent on the study. Copyright Springer-Verlag Berlin Heidelberg 2015

Keywords: Systematic review; Cost-effectiveness; Implantable cardioverter defibrillator; Prevention; Sudden cardiac death; Heart failure; I19 (search for similar items in EconPapers)
Date: 2015
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DOI: 10.1007/s10198-014-0637-x

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