Methodological challenges in assessing the impact of comorbidities on costs in Alzheimer’s disease clinical trials

Kristin Kahle-Wrobleski (), Howard Fillit, Jonathan Kurlander, Catherine Reed and Mark Belger

The European Journal of Health Economics, 2015, vol. 16, issue 9, 995-1004

Abstract: The number of comorbidities, alone or when combined with concomitant medications, did not impact baseline costs of care, perhaps because RCTs often enroll less severely ill and more medically stable patients. However, higher costs were consistently associated with greater functional impairment similar to non-RCT databases. Supplemental sources (e.g., claims databases) are likely needed to better estimate the effects of disease and treatment on costs of illness captured in RCTs for AD. Copyright The Author(s) 2015

Keywords: Alzheimer’s disease; Randomized controlled trials; Semagacestat; Comorbidities; Concomitant medications; Economics; I120 (health production); C900 (design of experiments) (search for similar items in EconPapers)
Date: 2015
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DOI: 10.1007/s10198-014-0648-7

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