Patient and general population values for luminal and perianal fistulising Crohn’s disease health states

Fanni Rencz (), Peep F. M. Stalmeier, Márta Péntek, Valentin Brodszky, Gábor Ruzsa, Lóránt Gönczi, Károly Palatka, László Herszényi, Eszter Schäfer, János Banai, Mariann Rutka, László Gulácsi and Peter L. Lakatos
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Fanni Rencz: Corvinus University of Budapest
Peep F. M. Stalmeier: Radboud University Medical Centre
Márta Péntek: Corvinus University of Budapest
Gábor Ruzsa: Eötvös Loránd University of Sciences
Lóránt Gönczi: Semmelweis University
Károly Palatka: University of Debrecen
László Herszényi: Hungarian Defence Forces
Eszter Schäfer: Hungarian Defence Forces
János Banai: Hungarian Defence Forces
Mariann Rutka: University of Szeged
László Gulácsi: Corvinus University of Budapest
Peter L. Lakatos: Semmelweis University

The European Journal of Health Economics, 2019, vol. 20, issue 1, No 9, 100 pages

Abstract: Abstract Background In patients with Crohn’s disease (CD), luminal disease activity paralleled by perianal fistulas may seriously impair health-related quality of life (HRQoL). Health utility values are not available from patients with CD that reflect the health loss associated with both luminal and perianal CD. Objective To generate utilities for luminal and concomitant perianal fistulising CD health states directly from patients and from members of the general public. Methods A cross-sectional survey was undertaken enrolling CD patients and a convenience sample of members of the general population. Respondents were asked to evaluate four common CD heath states [severe luminal disease (sCD), mild luminal disease (mCD), severe luminal disease with active perianal fistulas (sPFCD), and mild luminal disease with active perianal fistulas (mPFCD)] by 10-year time trade-off (TTO). In addition, patients assessed their current HRQoL by the TTO method. Results Responses of 206 patients (40.8% with perianal fistulas) and 221 members of the general population were analysed. Mean ± SD utilities among patients for sPFCD, sCD, mPFCD and mCD states were 0.69 ± 0.33, 0.73 ± 0.31, 0.80 ± 0.29 and 0.87 ± 0.26. Corresponding values in the general public were: 0.59 ± 0.31, 0.65 ± 0.29, 0.80 ± 0.26 and 0.88 ± 0.25. Patients with active perianal fistulas, previous non-resection surgeries, and higher pain intensity scores valued their current health as worse (p

Keywords: Crohn’s disease; Perianal fistula; Quality of life; Time trade-off; Utility; QALY; Hungary (search for similar items in EconPapers)
JEL-codes: I10 (search for similar items in EconPapers)
Date: 2019
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DOI: 10.1007/s10198-019-01065-y

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