Health state utilities associated with post-surgical Staphylococcus aureus infections

Louis S. Matza (), Katherine J. Kim (), Holly Yu (), Katherine A. Belden (), Antonia F. Chen (), Mark Kurd (), Bruce Y. Lee () and Jason Webb ()
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Louis S. Matza: Evidera
Katherine J. Kim: Evidera
Holly Yu: Pfizer Inc
Katherine A. Belden: Thomas Jefferson University
Antonia F. Chen: Harvard Medical School
Mark Kurd: Thomas Jefferson University The Rothman Institute
Bruce Y. Lee: Johns Hopkins University Bloomberg School of Public Health
Jason Webb: Southmead Hospital

The European Journal of Health Economics, 2019, vol. 20, issue 6, No 4, 819-827

Abstract: Abstract Introduction Surgical site infections (SSIs) are among the most common and potentially serious complications after surgery. Staphylococcus aureus is a virulent pathogen frequently identified as a cause of SSI. As vaccines and other infection control measures are developed to reduce SSI risk, cost-utility analyses (CUA) of these interventions are needed to inform resource allocation decisions. A recent systematic review found that available SSI utilities are of “questionable quality.” Therefore, the purpose of this study was to estimate the disutility (i.e., utility decrease) associated with SSIs. Methods In time trade-off interviews, general population participants in the UK (London, Edinburgh) valued health states drafted based on literature and clinician interviews. Health states described either joint or spine surgery, with or without an SSI. The utility difference between otherwise identical health states with and without the SSI represented the disutility associated with the SSI. Results A total of 201 participants completed interviews (50.2% female; mean age = 46.2 years). Mean (SD) utilities of health states describing joint and spine surgery without infections were 0.79 (0.23) and 0.78 (0.23). Disutilities of SSIs ranged from − 0.03 to − 0.32, depending on severity of the infection and subsequent medical interventions. All differences between corresponding health with and without SSIs were statistically significant (all p

Keywords: Utility; Time trade-off; Surgical site infection; SSI; Surgery; Staphylococcus aureus (search for similar items in EconPapers)
JEL-codes: I00 (search for similar items in EconPapers)
Date: 2019
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DOI: 10.1007/s10198-019-01036-3

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