Interchangeability of the EQ-5D and the SF-6D, and comparison of their psychometric properties in a spinal postoperative Spanish population

Carmen Selva-Sevilla (), Paula Ferrara and Manuel Gerónimo-Pardo
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Carmen Selva-Sevilla: Facultad de Ciencias Económicas y Empresariales de Albacete, Universidad de Castilla La-Mancha
Paula Ferrara: Complejo Hospitalario Universitario de Albacete
Manuel Gerónimo-Pardo: Complejo Hospitalario Universitario de Albacete

The European Journal of Health Economics, 2020, vol. 21, issue 4, No 12, 649-662

Abstract: Abstract Objective EuroQol-5D (EQ-5D) and Short-Form Six-Dimensions (SF-6D) are widely used to calculate quality-adjusted life-years in cost-utility analysis. The choice of the instrument could influence the results of cost-utility analysis. Our objective was to compare the psychometric properties of the EQ-5D and SF-6D in a postoperative Spanish population, as well as assess their interchangeability in a cost-utility analysis. Design Ambispective study. Setting Tertiary public hospital. Participants 275 Spanish patients who had undergone surgery for lumbar disc herniation. Intervention(s) Patients completed EQ-5D-3L and Short-Form 36 (SF-36v2) questionnaires. Internal consistency, floor and ceiling effects, agreement, and construct validity (convergent validity, including dimension-to-dimension correlations, and “known groups” validity) were assessed. The Spanish tariffs were applied. Main outcome measure(s) Cronbach’s α coefficient, Spearman’s rank correlation coefficient, Lin’s concordance correlation coefficient, intraclass correlation coefficient and Bland–Altman plot. Results Main findings were: (a) lack of agreement between EQ-5D and SF-6D utilities (Lin’s concordance correlation coefficient: 0.664 [95% CI: 0.600–0.720]; the Bland–Altman plot showed a mean difference of 0.0835 and wide limits of agreement [− 0.2602–0.4272]). (b) Lack of correlation between domains that theoretically measure similar aspects of quality of life, with the exception of “pain” domain. Conclusions The preference-based EQ-5D and SF-6D instruments showed valid psychometric properties to assess generic outcome in a Spanish population who had undergone surgery for lumbar disc herniation; however, utility scores derived from the measures were different. Thus, these two instruments cannot be used interchangeably to perform a cost-utility analysis, and they should both be included in sensitivity analyses.

Keywords: Patient-reported outcome measure; EuroQoL-5D (EQ-5D); Short-Form Six-Dimensions (SF-6D); Spanish version; Psychometric properties; Interchangeability (search for similar items in EconPapers)
JEL-codes: D7 I10 (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1007/s10198-020-01161-4

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