Budget impact analysis of the use of oral and intravenous therapy regimens for the treatment of relapsed or refractory multiple myeloma in Germany

Edin Basic (), Mathias Kappel, Arpit Misra, Leopold Sellner, Boris A. Ratsch and Dennis A. Ostwald
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Edin Basic: Takeda Pharma Vertrieb GmbH & Co. KG
Mathias Kappel: Health Economics, WifOR
Arpit Misra: Health Economics, WifOR
Leopold Sellner: Takeda Pharma Vertrieb GmbH & Co. KG
Boris A. Ratsch: Takeda Pharma Vertrieb GmbH & Co. KG
Dennis A. Ostwald: Health Economics, WifOR

The European Journal of Health Economics, 2020, vol. 21, issue 9, No 6, 1361 pages

Abstract: Abstract Background In Germany, several triplet therapies for treating relapsed or refractory multiple myeloma (rrMM) patients have recently been approved. While most of them are administered intravenously, ixazomib-based combination is the only orally bioavailable regimen. Objective To conduct a 1-year and 3-year budget impact analysis (BIA) of different novel triplets to treat patients with rrMM in second or subsequent therapy lines accounting for costs covered by German statutory health insurance (SHI). Methods A 3-state partitioned survival model (PSM) was developed to evaluate the budget impact of the following regimens: carfilzomib plus lenalidomide plus dexamethasone (KRd), elotuzumab plus lenalidomide plus dexamethasone (ERd), daratumumab plus lenalidomide plus dexamethasone (DRd), and ixazomib plus lenalidomide plus dexamethasone (IRd). The analysis included direct medical costs such as drug acquisition, comedication and preparation for parenteral solutions, drug administration and other 1-time costs, adverse event management costs and direct non-medical costs, such as transportation costs. Results Based on current drug market shares in German healthcare market, the estimated costs after 1 year of treatment was €551 million (KRd), €163 million (ERd), €584 million (DRd), and €95 million (IRd). The total budget impact of €1393 million is mainly driven by drug acquisition and subsequent therapy costs. Conclusion Among the regimens of interest, the oral-based therapy regimens offered cost advantages over intravenous-based therapy regimens. The higher overall costs of intravenous therapy regimens were attributed primarily to higher drug acquisition costs.

Keywords: Budget impact analysis; Relapsed/refractory multiple myeloma; Progression-free survival; Partitioned survival analysis; Intravenous therapies; Oral therapies (search for similar items in EconPapers)
JEL-codes: I11 (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1007/s10198-020-01219-3

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