Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly
Bing Xing (),
Shuyang Zhang () and
Dong Dong ()
Additional contact information
Kailu Wang: The Chinese University of Hong Kong
Xiaopeng Guo: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Siyue Yu: The Chinese University of Hong Kong
Lu Gao: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Zihao Wang: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Huijuan Zhu: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Bing Xing: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Shuyang Zhang: China Alliance of Rare Diseases
Dong Dong: The Chinese University of Hong Kong
The European Journal of Health Economics, 2021, vol. 22, issue 9, No 5, 1391 pages
Abstract Objective This study aimed to develop a mapping function that links the acromegaly quality of life (AcroQoL) questionnaire to EQ-5D-5L to obtain a preference-based utility value to inform economic evaluation. Methods A nationwide cross-sectional questionnaire survey among patients with acromegaly was conducted online in China during 17 December 2019 to 6 January 2020. The study sample was randomly divided into a training set and a validation set. Ordinary least squares (OLS), Tobit, beta-based mixture, and adjusted limited dependent variable mixture models were tested for development of the function in the training set. Total and subscale scores and individual items of AcroQoL were included as predictors in the models along with their squared terms and demographic and clinical characteristics, and selected by backward stepwise selection. The root mean square error, mean absolute error, Akaike’s information criterion, Bayesian information criterion and adjusted R-square were used to assess goodness of fit and predictive ability of the models. Results There were 424 adult patients with acromegaly eligible for this analysis. Average EQ-5D-5L index score and AcroQoL score for them was 0.82 (SD = 0.15) and 44.3 (SD = 22.9), respectively. A total of 60 candidate models were tested. Considering model simplicity and predictive ability in both training and validation set, the best model was the OLS model using scores of physical dimension and its square term as predictors. Conclusion A validated mapping function was developed in this study for estimating EQ-5D scores using AcroQoL outcomes. Its external validity can be further tested in other population with Acromegaly.
Keywords: Mapping; Quality of life; EQ-5D; Acromegaly; AcroQoL (search for similar items in EconPapers)
JEL-codes: I19 (search for similar items in EconPapers)
References: View references in EconPapers View complete reference list from CitEc
Citations: Track citations by RSS feed
Downloads: (external link)
http://link.springer.com/10.1007/s10198-021-01318-9 Abstract (text/html)
Access to the full text of the articles in this series is restricted.
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
Persistent link: https://EconPapers.repec.org/RePEc:spr:eujhec:v:22:y:2021:i:9:d:10.1007_s10198-021-01318-9
Ordering information: This journal article can be ordered from
http://www.springer. ... cs/journal/10198/PS2
Access Statistics for this article
The European Journal of Health Economics is currently edited by J.-M.G.v.d. Schulenburg
More articles in The European Journal of Health Economics from Springer, Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ) Contact information at EDIRC.
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().