HIT-6 and EQ-5D-5L in patients with migraine: assessment of common latent constructs and development of a mapping algorithm

Ana Sofia Oliveira Gonçalves (), Dimitra Panteli (), Lars Neeb (), Tobias Kurth () and Annette Aigner ()
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Ana Sofia Oliveira Gonçalves: Charité - Universitätsmedizin, Berlin
Dimitra Panteli: Technische Universität Berlin
Lars Neeb: Charité - Universitätsmedizin Berlin
Tobias Kurth: Charité - Universitätsmedizin, Berlin
Annette Aigner: Charité - Universitätsmedizin Berlin

The European Journal of Health Economics, 2022, vol. 23, issue 1, No 5, 47-57

Abstract: Abstract Objective The aims of this study were to assess whether there is a conceptual overlap between the questionnaires HIT-6 and EQ-5D and to develop a mapping algorithm allowing the conversion of HIT-6 to EQ-5D utility scores for Germany. Methods This study used data from an ongoing randomised controlled trial for patients suffering from migraine. We assessed the conceptual overlap between the two instruments with correlation matrices and exploratory factor analysis. Linear regression, tobit, mixture, and two-part models were used for mapping, accounting for repeated measurements, tenfold cross-validation was conducted to validate the models. Results We included 1010 observations from 410 patients. The EQ-5D showed a substantial ceiling effect (47.3% had the highest score) but no floor effect, while the HIT-6 showed a very small ceiling effect (0.5%). The correlation between the instruments’ total scores was moderate (− 0.30), and low to moderate among each domain (0.021–0.227). The exploratory factor analysis showed insufficient conceptual overlap between the instruments, as they load on different factors. Thus, there is reason to believe that the instruments’ domains do not capture the same latent constructs. To facilitate future mapping, we provide coefficients and a variance–covariance matrix for the preferred model, a two-part model with the total HIT-6 score as the explanatory variable. Conclusion This study showed that the German EQ-5D and the HIT-6 lack the conceptual overlap needed for appropriate mapping. Thus, the estimated mapping algorithms should only be used as a last resort for estimating utilities to be employed in economic evaluations.

Keywords: Mapping; EQ-5D; QALY; Utilities; HIT-6; Migraine (search for similar items in EconPapers)
JEL-codes: C3 I1 (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/s10198-021-01342-9

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