The EORTC QLU-C10D is a valid cancer-specific preference-based measure for cost-utility and health technology assessment in the Netherlands

Micha J. Pilz, Simon Seyringer, Lára R. Hallsson, Andrew Bottomley, Femke Jansen, Madeleine T. King, Richard Norman, Marianne J. Rutten, Irma M. Verdonck- de Leeuw, Peter D. Siersema and Eva Maria Gamper ()
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Micha J. Pilz: University Hospital of Psychiatry II, Medical University Innsbruck
Simon Seyringer: Medical University of Innsbruck
Lára R. Hallsson: Health Services Research and Health Technology Assessment, UMIT TIROL - University for Health Sciences and Technology
Andrew Bottomley: European Organisation for Research and Treatment of Cancer
Femke Jansen: Amsterdam UMC Location Vrije Universiteit Amsterdam
Madeleine T. King: University of Sydney
Richard Norman: Curtin University
Marianne J. Rutten: Amsterdam UMC
Irma M. Verdonck- de Leeuw: Amsterdam UMC Location Vrije Universiteit Amsterdam
Peter D. Siersema: Radboud University Medical Center
Eva Maria Gamper: University Hospital of Psychiatry II, Medical University Innsbruck

The European Journal of Health Economics, 2024, vol. 25, issue 9, No 6, 1539-1555

Abstract: Abstract Background Cost-utility analysis typically relies on preference-based measures (PBMs). While generic PBMs are widely used, disease-specific PBMs can capture aspects relevant for certain patient populations. Here the EORTC QLU-C10D, a cancer-specific PBM based on the QLQ-C30, is validated using Dutch trial data with the EQ-5D-3L as a generic comparator measure. Methods We retrospectively analysed data from four Dutch randomised controlled trials (RCTs) comprising the EORTC QLQ-C30 and the EQ-5D-3L. Respective Dutch value sets were applied. Correlations between the instruments were calculated for domains and index scores. Bland–Altman plots and intra-class correlations (ICC) displayed agreement between the measures. Independent and paired t-tests, effect sizes and relative validity indices were used to determine the instruments’ performance in detecting clinically known-group differences and health changes over time. Results We analysed data from 602 cancer patients from four different trials. In overall, the EORTC QLU-C10D showed good relative validity with the EQ-5D-3L as a comparator (correlations of index scores r = 0.53–0.75, ICCs 0.686–0.808, conceptually similar domains showed higher correlations than dissimilar domains). Most importantly, it detected 63% of expected clinical group differences and 50% of changes over time in patients undergoing treatment. Both instruments showed poor performance in survivors. Detection rate and measurement efficiency were clearly higher for the QLU-C10D than for the EQ-5D-3L. Conclusions The Dutch EORTC QLU-C10D showed good comparative validity in patients undergoing treatment. Our results underline the benefit that can be achieved by using a cancer-specific PBM for generating health utilities for cancer patients from a measurement perspective.

Keywords: Cancer-specific preference-based measure; EORTC QLU-C10D; EQ-5D-3L; Validity; Responsiveness (search for similar items in EconPapers)
JEL-codes: I18 (search for similar items in EconPapers)
Date: 2024
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DOI: 10.1007/s10198-024-01670-6

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