Psychometric performance of EQ-5D-5L and SF-6Dv2 in patients with lymphoma in China

Aixue Zhang, Jing Li, Zhuxin Mao, Zitong Wang, Jing Wu, Nan Luo, Peng Liu () and Pei Wang ()
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Aixue Zhang: Fudan University
Jing Li: Fudan University
Zhuxin Mao: University of Antwerp
Zitong Wang: Fudan University
Jing Wu: Tianjin University
Nan Luo: National University of Singapore
Peng Liu: Fudan University
Pei Wang: Fudan University

The European Journal of Health Economics, 2024, vol. 25, issue 9, No 1, 1484 pages

Abstract: Abstract Aim To assess and compare the measurement properties of EQ-5D-5L and SF-6Dv2 among lymphoma patients in China. Methods A face-to-face survey of Chinese lymphoma patients was conducted at baseline (all types) and follow-up (diffuse large B-cell). EQ-5D-5L and SF-6Dv2 health utility scores (HUSs) were calculated using the respective Chinese value sets. Ceiling effect was assessed by calculating the percentage of respondents reporting the optimal health state. Convergent validity of EQ-5D-5L and SF-6Dv2 was assessed using the Spearman rank correlation coefficient (r) with QLQ-C30 as a calibration standard. Known-groups validity of the two HUSs was evaluated by comparing their scores of patients with different conditions; and their sensitivity was further assessed in the known-groups using relative efficiency (RE). Test–retest reliability and responsiveness was tested using ICC and standardized response mean (SRM), respectively. Results Altogether 200 patients were enrolled at baseline and 78 were followed up. No ceiling effect was found for SF-6Dv2 compared to 24.5% for EQ-5D-5L. Correlation between the two HUSs and with QLQ-C30 score was strong (r > 0.5). Each dimension of EQ-5D-5L and SF-6Dv2 had moderate or greater correlations with similar dimensions of QLQ-C30 (r > 0.35). Both EQ-5D-5L and SF-6Dv2 could only a minority known-groups, and the latter may have better sensitivity. EQ-5D-5L had better test–retest reliability (ICC = 0.939); while both of them were responsive to patients with worsened and improved clinical status. Conclusions EQ-5D-5L and SF-6Dv2 were found to have good convergent validity and responsiveness, while EQ-5D-5L had better test–retest reliability and higher ceiling effect. Not enough evidence indicates which of the two measures has better known-group validity and sensitivity.

Keywords: Lymphoma; EQ-5D-5L; SF-6Dv2; Measurement properties; Health-related quality of life (search for similar items in EconPapers)
JEL-codes: I1 (search for similar items in EconPapers)
Date: 2024
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DOI: 10.1007/s10198-024-01672-4

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