Psychometric validation of the Chinese versions of EQ-5D-Y-3L and the experimental EQ-TIPS in children and adolescents with COVID-19

Wenjing Zhou (), Yaqin Li, Jan Busschbach, Michael Herdman, Zhihao Yang and Yanming Lu ()
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Wenjing Zhou: Shanghai Jiaotong University
Yaqin Li: Shanghai Jiaotong University
Jan Busschbach: Erasmus Medical Center
Michael Herdman: National University of Singapore
Zhihao Yang: Guizhou Medical University
Yanming Lu: Shanghai Jiaotong University

The European Journal of Health Economics, 2025, vol. 26, issue 3, No 1, 337-351

Abstract: Abstract Objectives Respiratory infectious diseases like COVID-19 profoundly impacts the health of children and adolescents, but validated instruments to measure their impacts on health-related quality of life (HRQoL) are lacking. The EQ-5D-Y-3L, widely used for youth HRQoL, now features a Chinese value set. The experimental EQ-TIPS addresses HRQoL assessment for toddlers and infants. This study tested the psychometric properties of both instruments in paediatric COVID-19 patients, and compared the performance of self-complete and proxy EQ-5D-Y-3L. Methods This longitudinal study recruited 861 COVID-19 patients aged 0–18 years and their parental caregivers, with 311 dyads completing the follow-up. Digital administration included the EQ-TIPS, the EQ-5D-Y-3L, and Overall Health Assessment (OHA). Controls comprised 231 healthy children. Analysis encompassed known-group validity, child-parent agreement, and responsiveness to change in disease severity and OHA. Results COVID-19 children exhibited lower HRQoL than non-infected peers. The EQ-TIPS and the EQ-5D-Y-3L distinguished groups by disease presence, severity and symptoms, showing moderate to good known-group validity (ESs: 0.45–1.39 for EQ-TIPS, 0.44–1.91 for self-complete EQ-5D-Y-3L, and 0.32–1.67 for proxy EQ-5D-Y-3L). Child-parent agreement was moderate to good for EQ-5D-Y-3L (ICC: 0.653–0.823; Gwet’s AC1: 0.470–0.738), and responsiveness was good for both EQ-TIPS Level Sum Score (LSS) (ESs: 1.21–1.39) and EQ-5D-Y-3L index scores (ESs: 1.00–1.16). Conclusions This study demonstrates the reliability, validity, and responsiveness of the experimental EQ-TIPS and the EQ-5D-Y-3L in paediatric COVID-19 patients. It is the first evidence of the EQ-TIPS’ responsiveness, supporting its use in assessing the impact of COVID-19 on paediatric HRQoL.

Keywords: COVID-19; EQ-5D-Y-3L; EQ-TIPS; Health-related quality of life; Validation; I19 (search for similar items in EconPapers)
Date: 2025
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DOI: 10.1007/s10198-024-01710-1

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