Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE ε4 genotype status: the Mayo Clinic Study of Aging

Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Bettina Barisch-Fritz, Sandra Trautwein, Klaus Boes, Alexander Woll, Walter K. Kremers, Mary M. Machulda, Michelle M. Mielke, David S. Knopman, Ronald C. Petersen and Yonas E. Geda ()
Additional contact information
Janina Krell-Roesch: Mayo Clinic
Jeremy A. Syrjanen: Mayo Clinic
Maria Vassilaki: Mayo Clinic
Bettina Barisch-Fritz: Karlsruhe Institute of Technology
Sandra Trautwein: Karlsruhe Institute of Technology
Klaus Boes: Karlsruhe Institute of Technology
Alexander Woll: Karlsruhe Institute of Technology
Walter K. Kremers: Mayo Clinic
Mary M. Machulda: Mayo Clinic
Michelle M. Mielke: Mayo Clinic
David S. Knopman: Mayo Clinic
Ronald C. Petersen: Mayo Clinic
Yonas E. Geda: Mayo Clinic

European Journal of Ageing, 2019, vol. 16, issue 4, No 9, 502 pages

Abstract: Abstract In this study derived from the population-based Mayo Clinic Study of Aging, we investigated whether non-exercise physical activity (PA) was associated with global and domain-specific cognitive trajectories (memory, language, visuospatial skills, attention) and whether the association differed by apolipoprotein E (APOE) ε4 genotype status. We included 2061 community-dwelling individuals aged ≥ 70 years (50.5% males, 26.7% APOE ε4 carriers) who were cognitively unimpaired at baseline and on whom serial cognitive data and self-reported information on non-exercise PA were available. We specifically inquired about non-exercise PA carried out at two time points, i.e., midlife (between 50 and 65 years of age) and late-life (within 1 year prior to assessment) and three intensity levels, i.e., light (e.g., laundry), moderate (e.g., scrubbing floors) and heavy (e.g., hard manual labor). Linear mixed-effect models revealed that engaging in midlife PA of moderate or heavy intensity was associated with significantly less-pronounced decline of z-scores in all cognitive domains. Similarly, participants that engaged in late-life moderate or heavy PA had less decline in visuospatial, attention and global z-scores than non-active peers. These associations varied depending on APOE ε4 carrier status, i.e., APOE ε4 non-carriers but not APOE ε4 carriers that engaged in late-life PA had less decline in cognitive z-scores. In contrast, engaging in midlife PA, irrespective of intensity, was significantly associated with less decline in memory function only among APOE ε4 carriers.

Keywords: Non-exercise physical activity; Cognitive trajectories; APOE ε4; Population-based study (search for similar items in EconPapers)
Date: 2019
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DOI: 10.1007/s10433-019-00513-1

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