Cardiovascular risk profiles and 20-year mortality in older people: gender differences in the Pro.V.A. study

Caterina Trevisan (), Giulia Capodaglio, Eliana Ferroni, Ugo Fedeli, Marianna Noale, Giovannella Baggio, Enzo Manzato, Stefania Maggi, Maria Chiara Corti and Giuseppe Sergi
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Caterina Trevisan: University of Padova
Giulia Capodaglio: Epidemiological System of the Veneto Region
Eliana Ferroni: Epidemiological System of the Veneto Region
Ugo Fedeli: Epidemiological System of the Veneto Region
Marianna Noale: Neuroscience Institute
Giovannella Baggio: Italian Center for the Studies on Gender Health and Medicine
Enzo Manzato: University of Padova
Stefania Maggi: Neuroscience Institute
Maria Chiara Corti: Epidemiological System of the Veneto Region
Giuseppe Sergi: University of Padova

European Journal of Ageing, 2022, vol. 19, issue 1, No 5, 37-47

Abstract: Abstract The age- and gender-related cardio-metabolic changes may limit the applicability of guidelines for the prevention of cardiovascular diseases (CVD) in older people. We investigated the association of cardiovascular risk profile with 20-year all-cause and CVD-mortality in older adults, focusing on age- and gender-specific differences. This prospective study involved 2895 community-dwelling individuals aged ≥65 years who participated in the Pro.V.A study. The sum of achieved target levels (smoking, diet, physical activity, body weight, blood pressure, lipids, and diabetes) recommended by the European Society of Cardiology 2016 guidelines was assessed in each participant. From this sum, cardiovascular risk profile was categorised as very high (0–2), high (3), medium (4), low (5), and very low (6–7 target levels achieved). All-cause and CV mortality data over 20 years were obtained from health registers. At Cox regression, lower cardiovascular risk profile was associated with reduced 20-year all-cause mortality in both genders, with stronger results for women (HR = 0.42 [95%CI:0.25–0.69] and HR = 0.61 [95%CI:0.42–0.89] for very low vs. very high cardiovascular risk profile in women and men, respectively). This trend was more marked for CVD mortality. Lower cardiovascular risk profile was associated with reduced all-cause and CVD mortality only in men

Keywords: Cardiovascular risk factors; Mortality; Gender differences; Older age (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/s10433-021-00620-y

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