Phase transitions in unstable cancer cell populations

R. Solé ()

The European Physical Journal B: Condensed Matter and Complex Systems, 2003, vol. 35, issue 1, 117-123

Abstract: The dynamics of cancer evolution is studied by means of a simple quasispecies model involving cells displaying high levels of genetic instability. Both continuous, mean-field and discrete, bit-string models are analysed. The string model is simulated on a single-peak landscape. It is shown that a phase transition exists at high levels of genetic instability, thus separating two phases of slow and rapid growth. The results suggest that, under a conserved level of genetic instability the cancer cell population will be close to the threshold level. Implications for therapy are outlined. Copyright Springer-Verlag Berlin/Heidelberg 2003

Date: 2003
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
http://hdl.handle.net/10.1140/epjb/e2003-00262-8 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:eurphb:v:35:y:2003:i:1:p:117-123

Ordering information: This journal article can be ordered from
http://www.springer.com/economics/journal/10051

DOI: 10.1140/epjb/e2003-00262-8

Access Statistics for this article

The European Physical Journal B: Condensed Matter and Complex Systems is currently edited by P. Hänggi and Angel Rubio

More articles in The European Physical Journal B: Condensed Matter and Complex Systems from Springer, EDP Sciences
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().