The relationship between target joints and direct resource use in severe haemophilia
Jamie O’Hara (),
Shaun Walsh (),
Charlotte Camp (),
Giuseppe Mazza (),
Liz Carroll (),
Christina Hoxer () and
Lars Wilkinson ()
Additional contact information
Jamie O’Hara: University of Chester
Shaun Walsh: HCD Economics, The Innovation Centre
Charlotte Camp: HCD Economics, The Innovation Centre
Giuseppe Mazza: University College London
Liz Carroll: The Haemophilia Society
Christina Hoxer: Novo Nordisk A/S
Lars Wilkinson: Novo Nordisk A/S
Health Economics Review, 2018, vol. 8, issue 1, 1-7
Abstract:
Abstract Objectives Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. Methods Data on haemophilia patients without inhibitors was drawn from the ‘Cost of Haemophilia across Europe – a Socioeconomic Survey’ (CHESS) study, a cost assessment in severe haemophilia A and B across five European countries (France, Germany, Italy, Spain, and the United Kingdom) in which 139 haemophilia specialists provided demographic and clinical information for 1285 adult patients. NDDCs were calculated using publicly available cost data, including 12-month ambulatory and secondary care activity: haematologist and other specialist consultant consultations, medical tests and examinations, bleed-related hospital admissions, and payments to professional care providers. A generalized linear model was developed to investigate the relationship between NDDCs and target joints (areas of chronic synovitis), adjusted for patient covariates. Results Five hundred and thirteen patients (42% of the sample) had no diagnosed target joints; a total of 1376 target joints (range 1–10) were recorded in the remaining 714 patients. Mean adjusted NDDCs for persons with no target joints were EUR 3134 (standard error (SE) EUR 158); for persons with one or more target joints, mean adjusted NDDCs were EUR 3913 (SE EUR 157; average mean effect EUR 779; p
Keywords: Haemophilia; Cost of illness; Target joints; Burden of disease; Arthropathy; Synovitis (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations:
Downloads: (external link)
http://link.springer.com/10.1186/s13561-018-0185-7 Abstract (text/html)
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:spr:hecrev:v:8:y:2018:i:1:d:10.1186_s13561-018-0185-7
Ordering information: This journal article can be ordered from
http://www.springer.com/journal/13561
DOI: 10.1186/s13561-018-0185-7
Access Statistics for this article
Health Economics Review is currently edited by J. Matthias Graf von der Schulenburg
More articles in Health Economics Review from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().