The efficacy and short-term effects of electronic cigarettes as a method for smoking cessation: a systematic review and a meta-analysis

S. Khoudigian (), T. Devji, L. Lytvyn, K. Campbell, R. Hopkins and D. O’Reilly
Additional contact information
S. Khoudigian: McMaster University
T. Devji: McMaster University
L. Lytvyn: McMaster University
K. Campbell: McMaster University
R. Hopkins: McMaster University
D. O’Reilly: McMaster University

International Journal of Public Health, 2016, vol. 61, issue 2, No 15, 257-267

Abstract: Abstract Objectives E-cigarettes are increasingly popular as smoking cessation aids. This review assessed the efficacy of e-cigarettes for smoking cessation as well as desire to smoke, withdrawal symptoms, and adverse events in adult smokers. Methods A systematic review was conducted. Studies comparing e-cigarettes to other nicotine replacement therapies or placebo were included. Data were pooled using meta-analysis. Results Of 569 articles, 5 were eligible. Study participants were more likely to stop smoking when using nicotine e-cigarettes (43/489, 9 %) versus placebo e-cigarettes (8/173, 5 %); however, this difference was not statistically significant (RR 2.02; 95 % CI 0.97, 4.22). The pooled effect estimates for the desire to smoke (RR −0.22; 95 % CI −0.80, 0.36), irritability (RR −0.03; 95% CI −0.38, 0.31), restlessness (RR −0.03; 95 % CI −0.42, 0.35), poor concentration (RR −0.01; 95 % CI −0.35, 0.32), depression (RR −0.01; 95 % CI −0.22, 0.20), hunger (RR −0.01; 95 % CI −0.32, 0.30), and average number of non-serious adverse events (RR −0.09; 95 % CI −0.28, 0.46) were not statistically significantly different. Only one study reported serious adverse events with no apparent association with e-cigarette use. Conclusions Limited low-quality evidence of a non-statistically significant trend toward smoking cessation in adults using nicotine e-cigarettes exists compared with other therapies or placebo. Larger, high-quality studies are needed to inform policy decisions.

Keywords: Meta-analysis; E-cigarettes; Smoking cessation; Withdrawal symptoms; Public health (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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DOI: 10.1007/s00038-016-0786-z

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