Cost-utility analysis of a nationwide vaccination programme against serogroup B meningococcal disease in Israel

Gary M. Ginsberg (), Colin Block and Chen Stein-Zamir
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Gary M. Ginsberg: Public Health Service, Ministry of Health
Colin Block: Hadassah-Hebrew University Medical Centre
Chen Stein-Zamir: Jerusalem District Health Office, Ministry of Health

International Journal of Public Health, 2016, vol. 61, issue 6, No 7, 683-692

Abstract: Abstract Objectives Using cost-utility analysis, to evaluate whether or not to adopt a Neisseria meningitidis serogroup B vaccination programme for Israeli children. Methods Epidemiological, demographic, health service utilisation and economic data were integrated into a spreadsheet model to calculate the cost per averted disability-adjusted life year (DALY) of the intervention. Results Assuming 78 % vaccine efficacy with no herd immunity, vaccination will prevent 223 cases and 22 deaths over a 100-year period. Based on vaccine price of $60 per dose, total intervention costs ($315,400,000) are partially offset by a $22,700,000 reduction in treatment and sequelae costs as a result of decreased morbidity. The intervention was not cost-effective since the net cost ($292,700,000) per averted DALY gained (1249 mostly due to decreased mortality) was $234,394. Additional two dose catch-up programmes vaccinating children in cohorts aged 1–2 to 1–13 were also not cost-effective. Conclusions The vaccination will become cost-effective if vaccine costs fall below $19.44 per dose. However, in identified high risk areas, the vaccine would be cost-effective and could be recommended for use both with and without catch-up campaigns.

Keywords: Cost-utility analysis; Meningococcal B; Vaccination; Economic evaluation (search for similar items in EconPapers)
Date: 2016
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Citations: View citations in EconPapers (2)

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DOI: 10.1007/s00038-016-0821-0

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