Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study

Minh Diem Dang, Duc Minh Nguyen, Huu Bich Tran, Viet Hung Pham, Daryl Spak, Linh Chi Pham, Thi Quynh Phan, Thi Thanh Dinh, Thi Kim Anh Le, Nguyen Van Lam, Thanh Hai Le, Son Ngoc Hoang and Vu Phuong Linh Dang ()
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Minh Diem Dang: Hanoi University of Public Health
Duc Minh Nguyen: National Hospital of Acupuncture
Huu Bich Tran: Hanoi University of Public Health
Viet Hung Pham: Vietnam National Hospital of Pediatrics
Daryl Spak: University of Buffalo School of Medicine and Biomedical Sciences
Linh Chi Pham: University of Washington
Thi Quynh Phan: Hanoi University of Public Health
Thi Thanh Dinh: Hanoi University of Public Health
Thi Kim Anh Le: Hanoi University of Public Health
Nguyen Van Lam: National Hospital of Acupuncture
Thanh Hai Le: National Hospital of Acupuncture
Son Ngoc Hoang: Viet Duc Hospital
Vu Phuong Linh Dang: Hanoi University of Public Health

International Journal of Public Health, 2017, vol. 62, issue 1, No 14, 113-119

Abstract: Abstract Objectives Over the past decades, Vietnam has made great strides in reducing the rate of mortality in HIV-related deaths, due to increased access of antiretroviral therapy (ART); however, given the significantly high level of treatment failure (TF), it is essential to identify markers that describe the failure of ART in HIV-1 infected children. Methods A nested case–control study was conducted with clinical data collected from 101 HIV-infected children [26 TF and 75 treatment success (TS)] at National Hospital of Pediatrics, Vietnam (2008–2012). Results The results showed that certain factors including height, weight, vaccination with Hepatitis B, and platelet were significantly different between TF and TS before starting the treatment. In addition, age to start the treatment, CD4 percentage, and opportunistic infection were found to significantly predict treatment outcome most frequently, implying the importance of clinical markers in the treatment response by Cox regression analysis. Conclusions There is an inherent complexity within clinical markers that is challenging to determine HIV-pediatric failure and further research is needed to build a complete picture to guide clinical, evidence-based practice.

Keywords: HIV-1; Pediatric; Treatment failure; ART (search for similar items in EconPapers)
Date: 2017
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DOI: 10.1007/s00038-016-0937-2

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