Relative contribution of health-related behaviours and chronic diseases to the socioeconomic patterning of low-grade inflammation

Marialaura Bonaccio (), Augusto Di Castelnuovo, George Pounis, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano and Licia Iacoviello
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Marialaura Bonaccio: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Augusto Di Castelnuovo: IRCCS Istituto Neurologico Mediterraneo NEUROMED
George Pounis: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Amalia De Curtis: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Simona Costanzo: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Mariarosaria Persichillo: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Chiara Cerletti: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Maria Benedetta Donati: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Giovanni de Gaetano: IRCCS Istituto Neurologico Mediterraneo NEUROMED
Licia Iacoviello: IRCCS Istituto Neurologico Mediterraneo NEUROMED

International Journal of Public Health, 2017, vol. 62, issue 5, No 4, 562 pages

Abstract: Abstract Objectives To test the association of low-grade inflammation with socioeconomic status (SES) and determine the relative contribution of prevalent chronic diseases and health-related behaviours in explaining such association. Methods Cross-sectional analysis on 19,867 subjects (age ≥35, 48.1% men) recruited within the Moli-sani study from 2005 to 2010 (Italy). A score of low-grade inflammation, including platelet and leukocyte counts, the granulocyte-to-lymphocyte ratio, and C-reactive protein was applied. SES was measured by education, household income, and occupational social class. Results Low SES was associated with elevated levels of low-grade inflammation. Health behaviours (including adiposity, smoking, physical activity, and Mediterranean diet adherence) explained 53.5, 53.9, and 84.9% of the association between social class, income, and education with low-grade inflammation, respectively. Adiposity and body mass index showed a prominent role, while prevalent chronic diseases and conditions only marginally attenuated SES inequalities in inflammation. Conclusions Low-grade inflammation was socioeconomically patterned in a large Mediterranean population. Potentially modifiable behavioural factors explained the greatest part of this association with a leading contribution of adiposity, body mass index, and physical activity.

Keywords: Moli-sani study; Socioeconomic status; Low-grade inflammation; Health-related behaviours; Chronic diseases (search for similar items in EconPapers)
Date: 2017
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DOI: 10.1007/s00038-016-0939-0

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