Moderate physical activity reduces 10-year diabetes incidence: the mediating role of oxidative stress biomarkers

Efi Koloverou, Konstantinos Tambalis, Dimosthenis Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis and Christos Pitsavos
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Efi Koloverou: Harokopio University
Konstantinos Tambalis: Harokopio University
Ekavi Georgousopoulou: Harokopio University
Christina Chrysohoou: University of Athens
Ioannis Skoumas: University of Athens
Dimitrios Tousoulis: University of Athens
Christodoulos Stefanadis: University of Athens
Christos Pitsavos: University of Athens

International Journal of Public Health, 2018, vol. 63, issue 2, No 16, 297-305

Abstract: Abstract Objectives To evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism. Methods In 2001–2002, a random sample of apparently healthy 3042 men and women (18–89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed. Diabetes diagnosis was defined according to the ADA criteria. During 2011–2012, a 10-year follow-up was performed. Results n = 191 cases were recorded, yielding an incidence of 12.9%. In multivariable analysis, moderate physical activity level (331–1484 MET min/week) was found to decrease 10-year diabetes incidence by 53% compared to very low physical activity ( 1484 MET min/week), the results were not significant. The antidiabetic effect was found to be mediated by oxidized LDL and total antioxidant capacity. Conclusions The current work revealed the significant beneficial role of moderate physical activity against diabetes development, potentially through attenuating oxidative stress.

Keywords: Physical activity; Diabetes incidence; Oxidative stress (search for similar items in EconPapers)
Date: 2018
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DOI: 10.1007/s00038-017-1052-8

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