Epidemiology and clinical course of primary biliary cholangitis in Eastern Slovakia

Sylvia Drazilova (), Ingrid Babinska (), Jakub Gazda (), Monika Halanova (), Martin Janicko (), Branislav Kucinsky (), Dominik Safcak (), Dominika Martinkova (), Lucia Tarbajova (), Anna Cekanova () and Peter Jarcuska ()
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Sylvia Drazilova: Hospital Poprad
Ingrid Babinska: PJ Safarik University, Faculty of Medicine
Jakub Gazda: PJ Safarik University
Monika Halanova: PJ Safarik University, Faculty of Medicine
Martin Janicko: PJ Safarik University
Branislav Kucinsky: PJ Safarik University
Dominik Safcak: PJ Safarik University
Dominika Martinkova: Hospital Poprad
Lucia Tarbajova: Hospital Poprad
Anna Cekanova: PJ Safarik University
Peter Jarcuska: PJ Safarik University

International Journal of Public Health, No 0, 9 pages

Abstract: Abstract Objective To determine both the incidence and the prevalence of primary biliary cholangitis (PBC) in Eastern Slovakia and to describe its clinical course and the response to ursodeoxycholic acid (UDCA). Methods We recorded data of patients with PBC, who were followed up in gastroenterology and hepatology centers in Eastern Slovakia during the period from June 30, 1999, through June 30, 2019. Results The annual incidence of PBC varied from 0.7 to 1.5 cases per 100,000 inhabitants between 2014 and 2018. PBC prevalence steadily increased from initial 10.2 cases per 100,000 inhabitants in 2014 to 14.9 cases per 100,000 inhabitants in June 2019. The mean age at the time of diagnosis was 56.3 ± 10.9 years. 95.7% of patients were females, and female/male gender ratio was 22.3:1. In June 2019, prevalence in the female population was 28 cases per 100,000 women. At the time of diagnosis, three-quarters of patients were symptomatic and 10% of patients had liver cirrhosis. The mean follow-up was 7.3 ± 5.2 years. Response to UDCA was observed in 72.1% of patients. Patients with higher baseline alkaline phosphatase (ALP) levels, liver cirrhosis at entry or at the end of follow-up and women younger than 45 years responded worse to UDCA. One-quarter of patients had liver cirrhosis at the end of follow-up. During follow-up, 1.6% of patients underwent liver transplantation and 5.5% of patients died. Five-year and 10-year liver-related mortalities were 2.7% and 4.3%, respectively. Conclusion PBC prevalence in Eastern Slovakia is increasing, and most of the patients respond to therapy with UDCA.

Keywords: Primary biliary cholangitis; Prevalence; Incidence; Clinical course; Ursodeoxycholic acid (search for similar items in EconPapers)
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DOI: 10.1007/s00038-020-01391-6

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