Modeling the mechanism pathways of first line drug in Tuberculosis using Petri nets

Gajendra Pratap Singh (), Madhuri Jha, Mamtesh Singh and Naina
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Gajendra Pratap Singh: Jawaharlal Nehru University
Madhuri Jha: Jawaharlal Nehru University
Mamtesh Singh: Gargi College (University of Delhi)
Naina: Jawaharlal Nehru University

International Journal of System Assurance Engineering and Management, 2020, vol. 11, issue 2, No 19, 313-324

Abstract: Abstract Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) in Tuberculosis (TB) is still a big threat worldwide, as it remains one of the leading causes of death. The main reason behind this is the Mycobacterium tuberculosis bacteria (Mtb) is being resistant towards first line drug (FLD). This is because of the mutation in certain genes like katG, pncA, rpoB, embABC. To have a better understanding of the mechanism behind the susceptibility and resistivity of drugs involved in FLD, we propose a graphical approach of modeling the whole process by using Petri net. The analysis of the model helps in improving the new drug techniques on the way to decrease the rate of MDR-TB and XDR-TB.

Keywords: Tuberculosis disease; Drug mechanism; First line drug; Petri net; Reachability graph; Marking vector; PIPEv4.3.0; WoPeD (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (1)

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DOI: 10.1007/s13198-019-00940-4

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