Fitting PB1-p62 filaments model structure into its electron microscopy based on an improved genetic algorithm

Zhihong Zhao, Beibei Li and Jun Liu ()
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Zhihong Zhao: Nanjing Institute of Industry Technology
Beibei Li: Shanghai Polytechnic University
Jun Liu: Shanghai Jiaotong University

Journal of Combinatorial Optimization, No 0, 11 pages

Abstract: Abstract This paper presents a method to realize fitting PDB of protein molecule PB1-p62 into its EM in PB1 domain, based on rotation group SO(3) theory. An image partition method is adopted on the EM images before performing sampling process. Different sample points are distributed on the different EM image partitioned areas. The number of these sample points may be controlled by an improved genetic algorithm. Through iteration, we may get the optimum and then obtain the satisfactory fitting.

Keywords: Sampling; Genetic algorithm; Electron microscope; Fitting (search for similar items in EconPapers)
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DOI: 10.1007/s10878-019-00483-1

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