A mathematical approach to solve the network reconstruction problem

Wolfgang Marwan, Annegret Wagler and Robert Weismantel ()

Mathematical Methods of Operations Research, 2008, vol. 67, issue 1, 117-132

Abstract: The reconstruction of biochemical and genetic networks from experimental data is an important challenge in biology and medical basic research. We formalize this problem mathematically and present an exact algorithm for its solution. Our procedure yields either a complete list of all alternative network structures that explain the observed phenomena or proves that no solution exists using the given data set. Copyright Springer-Verlag 2008

Keywords: Modeling biological systems; Integer decomposition; Reverse engineering (search for similar items in EconPapers)
Date: 2008
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DOI: 10.1007/s00186-007-0178-5

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