Asymptotic Distributions of Empirical Interaction Information

Mariusz Kubkowski and Jan Mielniczuk ()
Additional contact information
Mariusz Kubkowski: Institute of Computer Science Polish Academy of Sciences
Jan Mielniczuk: Institute of Computer Science Polish Academy of Sciences

Methodology and Computing in Applied Probability, 2021, vol. 23, issue 1, 291-315

Abstract: Abstract Interaction Information is one of the most promising interaction strength measures with many desirable properties. However, its use for interaction detection was hindered by the fact that apart from the simple case of overall independence, asymptotic distribution of its estimate has not been known. In the paper we provide asymptotic distributions of its empirical versions which are needed for formal testing of interactions. We prove that for three-dimensional nominal vector normalized empirical interaction information converges to the normal law unless the distribution coincides with its Kirkwood approximation. In the opposite case the convergence is to the distribution of weighted centred chi square random variables. This case is of special importance as it roughly corresponds to interaction information being zero and the asymptotic distribution can be used for construction of formal tests for interaction detection. The result generalizes result in Han (Inf Control 46(1):26–45 1980) for the case when all coordinate random variables are independent. The derivation relies on studying structure of covariance matrix of asymptotic distribution and its eigenvalues. For the case of 3 × 3 × 2 contingency table corresponding to study of two interacting Single Nucleotide Polymorphisms (SNPs) for prediction of binary outcome, we provide complete description of the asymptotic law and construct approximate critical regions for testing of interactions when two SNPs are possibly dependent. We show in numerical experiments that the test based on the derived asymptotic distribution is easy to implement and yields actual significance levels consistently closer to the nominal ones than the test based on chi square reference distribution.

Keywords: Interaction information; Asymptotic weighted chi square distribution; Linkage disequilibrium; Interaction detection; Primary 62G20; Secondary 60E99 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://link.springer.com/10.1007/s11009-020-09783-0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:metcap:v:23:y:2021:i:1:d:10.1007_s11009-020-09783-0

Ordering information: This journal article can be ordered from
https://www.springer.com/journal/11009

DOI: 10.1007/s11009-020-09783-0

Access Statistics for this article

Methodology and Computing in Applied Probability is currently edited by Joseph Glaz

More articles in Methodology and Computing in Applied Probability from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().