Modelling Outcomes of Complex Treatment Strategies Following a Clinical Guideline for Treatment Decisions in Patients with Rheumatoid Arthritis

An Tran-Duy (), Annelies Boonen, Wietske Kievit, Piet Riel, Mart Laar and Johan Severens

PharmacoEconomics, 2014, vol. 32, issue 10, 1015-1028

Abstract: It is possible to model the outcomes of complex treatment strategies based on a clinical guideline for the management of RA. Following the Dutch guideline and using real-life data, inclusion of BRMs in the treatment strategy for RA appeared to be less favourable in our model than in most of the existing models that compared drug sequences independent of patient characteristics and used data from randomised controlled clinical trials. Despite complexity and demand for extensive data, our modelling approach can help to identify the knowledge gaps in clinical guidelines for RA management and priorities for future research. Copyright Springer International Publishing Switzerland 2014

Date: 2014
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DOI: 10.1007/s40273-014-0184-4

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