A Review of the Psychometric Properties of Generic Utility Measures in Multiple Sclerosis

Ayse Kuspinar () and Nancy Mayo

PharmacoEconomics, 2014, vol. 32, issue 8, 759-773

Abstract: To our knowledge this is the first study to review the validity and reliability of generic utility measures in MS. The HUI3 demonstrated the strongest psychometric properties when compared with other utility measures. However, the HUI3 only measures impairment and excludes important components of HRQL such as participation restrictions. The EQ-5D, the SF-6D and the QWB scale, on the other hand, do include items on participation. However, these measures demonstrated a lack of content validity in MS by missing certain domains that were important to the disease, as well as difficulty in differentiating between different levels of disability. The addition of MS-specific ‘bolt-ons’ to generic utility measures and the development of an MS specific utility measure are possible areas of exploration for future research. Copyright Springer International Publishing Switzerland 2014

Date: 2014
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DOI: 10.1007/s40273-014-0167-5

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