Assessing the Value of Treatment to Address Various Symptoms Associated with Multiple Sclerosis: Results from a Contingent Valuation Study

Pei-Jung Lin (), Cayla J. Saret, Peter J. Neumann, Eileen A. Sandberg and Joshua T. Cohen
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Pei-Jung Lin: Tufts Medical Center
Cayla J. Saret: Tufts Medical Center
Peter J. Neumann: Tufts Medical Center
Eileen A. Sandberg: Tufts Medical Center
Joshua T. Cohen: Tufts Medical Center

PharmacoEconomics, 2016, vol. 34, issue 12, No 6, 1255-1265

Abstract: Abstract Background Although it is well recognized that people with multiple sclerosis (MS) may experience impairments in addition to limited mobility, there has been little effort to study their relative importance to patients with the condition. The objective of this study was to assess patient preferences for addressing various MS symptoms. Methods This study was conducted at Tufts Medical Center, Boston, Massachusetts. We developed a national online survey of MS patients and neurologists to estimate the value each group places on treating specific MS symptoms. Each respondent was presented with two randomly selected scenarios with different symptoms and treatments. MS patients were asked about their own preferences, whereas neurologists were asked to consider what a patient of theirs would do or think in each scenario. We used a bidding game approach to elicit respondents’ willingness to pay (WTP) for the treatments. Results To treat mobility alone, WTP for MS patients averaged US$410–US$520 per month, depending on the scenario. For paired symptoms, MS patients would pay most to treat mobility and upper limb function (US$525/month) or mobility and cognition (US$514/month), somewhat less to treat mobility and eyesight (US$445/month), and least to treat mobility and fatigue (US$371/month). Patient WTP values increased with income and education. Neurologists believed their patients would be willing to pay US$216–US$249 per month to treat mobility alone, depending on the scenario. For paired symptoms, neurologists believed patients would pay most to treat mobility and fatigue (US$263/month) and least to treat mobility and upper limb function (US$177/month). Conclusion Our findings suggest MS patients may value one outcome (e.g., improved arm and hand coordination) over another (e.g., less fatigue). Further, MS patients and neurologists may rank the importance of treating various symptoms differently. Given this potential mismatch, it is crucial for MS patients and their clinicians to discuss treatment priorities that take into account patient preferences.

Date: 2016
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DOI: 10.1007/s40273-016-0435-7

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