Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

Dyfrig Hughes (), Joanna Charles, Dalia Dawoud, Rhiannon Tudor Edwards, Emily Holmes, Carys Jones, Paul Parham, Catrin Plumpton, Colin Ridyard, Huw Lloyd-Williams, Eifiona Wood and Seow Tien Yeo
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Dyfrig Hughes: Ardudwy, Bangor University
Joanna Charles: Ardudwy, Bangor University
Dalia Dawoud: Cairo University
Rhiannon Tudor Edwards: Ardudwy, Bangor University
Emily Holmes: Ardudwy, Bangor University
Carys Jones: Ardudwy, Bangor University
Paul Parham: University of Liverpool
Catrin Plumpton: Ardudwy, Bangor University
Colin Ridyard: Ardudwy, Bangor University
Huw Lloyd-Williams: Ardudwy, Bangor University
Eifiona Wood: Ardudwy, Bangor University
Seow Tien Yeo: Ardudwy, Bangor University

PharmacoEconomics, 2016, vol. 34, issue 5, No 4, 447-461

Abstract: Abstract Trial-based economic evaluations are an important aspect of health technology assessment. The availability of patient-level data coupled with unbiased estimates of clinical outcomes means that randomised controlled trials are effective vehicles for the generation of economic data. However there are methodological challenges to trial-based evaluations, including the collection of reliable data on resource use and cost, choice of health outcome measure, calculating minimally important differences, dealing with missing data, extrapolating outcomes and costs over time and the analysis of multinational trials. This review focuses on the state of the art of selective elements regarding the design, conduct, analysis and reporting of trial-based economic evaluations. The limitations of existing approaches are detailed and novel methods introduced. The review is internationally relevant but with a focus towards practice in the UK.

Date: 2016
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DOI: 10.1007/s40273-015-0371-y

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