The Clinical Impact and Cost Effectiveness of Quadrivalent Versus Trivalent Influenza Vaccination in Finland

Lisa Nagy (), Terho Heikkinen, Alfred Sackeyfio and Richard Pitman
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Lisa Nagy: ICON Health Economics and Epidemiology
Terho Heikkinen: University of Turku and Turku University Hospital
Alfred Sackeyfio: AstraZeneca
Richard Pitman: ICON Health Economics and Epidemiology

PharmacoEconomics, 2016, vol. 34, issue 9, No 9, 939-951

Abstract: Abstract Background Trivalent influenza vaccines encompass one influenza B lineage; however, predictions have been unreliable on which of two antigenically distinct circulating lineages will dominate. Quadrivalent seasonal influenza vaccines contain strains from both lineages. This analysis assesses the cost effectiveness of switching from trivalent inactivated influenza vaccination (TIV) in Finland to quadrivalent vaccination, using inactivated (QIV) or live-attenuated (Q-LAIV) vaccines. Methods A transmission model simulated the dynamics of influenza infection while accounting for indirect (herd) protection. Prior distributions for key transmission parameters were repeatedly sampled and simulations that fitted the available information on influenza in Finland were recorded. The resulting posterior parameter distributions were used in a probabilistic sensitivity analysis in which economic parameters were sampled, simultaneously encompassing uncertainty in the transmission and economic parameters. The cost effectiveness of a range of trivalent and quadrivalent vaccine policies over a 20-year time horizon was assessed from both a societal and payer perspective in 2014 Euros. Results The simulated temporal incidence pattern of symptomatic infections corresponded well with case surveillance data. A switch from the current TIV to Q-LAIV in children (2 to

Date: 2016
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DOI: 10.1007/s40273-016-0430-z

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