The Potential Cost Effectiveness of Different Dengue Vaccination Programmes in Malaysia: A Value-Based Pricing Assessment Using Dynamic Transmission Mathematical Modelling

Asrul Shafie (), Hui Yee Yeo, Laurent Coudeville, Lucas Steinberg, Balvinder Singh Gill, Rohani Jahis and Amar-Singh Hss
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Hui Yee Yeo: Universiti Sains Malaysia (USM)
Laurent Coudeville: Sanofi Pasteur SA
Lucas Steinberg: Sanofi Pasteur Malaysia
Balvinder Singh Gill: Ministry of Health Malaysia
Rohani Jahis: Ministry of Health Malaysia
Amar-Singh Hss: Hospital Raja Permaisuri Bainun Ipoh, Jalan Hospital

PharmacoEconomics, 2017, vol. 35, issue 5, No 7, 575-589

Abstract: Abstract Background Dengue disease poses a great economic burden in Malaysia. Methods This study evaluated the cost effectiveness and impact of dengue vaccination in Malaysia from both provider and societal perspectives using a dynamic transmission mathematical model. The model incorporated sensitivity analyses, Malaysia-specific data, evidence from recent phase III studies and pooled efficacy and long-term safety data to refine the estimates from previous published studies. Unit costs were valued in $US, year 2013 values. Results Six vaccination programmes employing a three-dose schedule were identified as the most likely programmes to be implemented. In all programmes, vaccination produced positive benefits expressed as reductions in dengue cases, dengue-related deaths, life-years lost, disability-adjusted life-years and dengue treatment costs. Instead of incremental cost-effectiveness ratios (ICERs), we evaluated the cost effectiveness of the programmes by calculating the threshold prices for a highly cost-effective strategy [ICER

Date: 2017
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DOI: 10.1007/s40273-017-0487-3

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