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Are PCSK9 Inhibitors Cost Effective?

Max J. Korman, Kjetil Retterstøl, Ivar Sønbø Kristiansen and Torbjørn Wisløff ()
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Max J. Korman: Ministry of Local Government and Modernisation
Kjetil Retterstøl: University of Oslo
Ivar Sønbø Kristiansen: University of Oslo
Torbjørn Wisløff: University of Oslo

PharmacoEconomics, 2018, vol. 36, issue 9, 1031-1041

Abstract: Abstract The objective of this study was to review available health economic evaluations of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. These drugs reduce low-density lipid cholesterol levels and cardiovascular risk, but their cost effectiveness has been questioned. We searched Medline and Embase for economic evaluations in any language at any time. Studies were included if they analysed any PCSK9 inhibitor compared with either statin alone or in combination with ezetimibe or any other therapy considered standard prior to the introduction of PCSK9 inhibitors. We found ten full health economic evaluations of PCSK9 inhibitors, two from Europe and eight from the United States (US). Six of the eight from the US were from two different consortia that analysed PCSK9 inhibitors at different stages through the development of evidence. All studies generally reported incremental cost-effectiveness ratios above suggested thresholds for cost effectiveness, except one study from Spain. The results of this review indicate that PCSK9 inhibitors in general are not cost effective at the current prices, but lower prices may change the results.

Date: 2018
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