EQ-5D-5L Valuation for the Malaysian Population

Asrul Akmal Shafie (), Annushiah Vasan Thakumar, Ching Jou Lim, Nan Luo, Kim Rand-Hendriksen and Faridah Aryani Md Yusof
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Asrul Akmal Shafie: Universiti Sains Malaysia
Annushiah Vasan Thakumar: Universiti Sains Malaysia
Ching Jou Lim: Universiti Sains Malaysia
Nan Luo: National University of Singapore
Kim Rand-Hendriksen: Akershus University Hospital
Faridah Aryani Md Yusof: Ministry of Health Malaysia

PharmacoEconomics, 2019, vol. 37, issue 5, No 8, 715-725

Abstract: Abstract Objectives The aim of this study was to develop an EQ-5D-5L value set reflecting the health preferences of the Malaysian adult population. Methods Respondents were sampled with quotas for urbanicity, gender, age, and ethnicity to ensure representativeness of the Malaysian population. The study was conducted using a standardized protocol involving the EuroQol Valuation Technology (EQ-VT) computer-assisted interview system. Respondents were administered ten composite time trade-off (C-TTO) tasks and seven discrete choice experiment (DCE) tasks. Both linear main effects and constrained non-linear regression models of C-TTO-only data and hybrid models combining C-TTO and DCE data were explored to determine an efficient and informative model for value set prediction. Results Data from 1125 respondents representative of the Malaysian population were included in the analysis. Logical consistency was present in all models tested. Using cross-validation, eight-parameter models for C-TTO only and C-TTO + DCE hybrid data displayed greater out-of-sample predictive accuracy than their 20-parameter, main-effect counterparts. The hybrid eight-parameter model was chosen to represent the Malaysian value set, as it displayed greater out-of-sample predictive accuracy over C-TTO data than the C-TTO-only model, and produced more precise estimates. The estimated value set ranged from − 0.442 to 1. Conclusions The constrained eight-parameter hybrid model demonstrated the best potential in representing the Malaysian value set. The presence of the Malaysian EQ-5D-5L value set will facilitate its application in research and health technology assessment activities.

Date: 2019
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Citations: View citations in EconPapers (5)

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DOI: 10.1007/s40273-018-0758-7

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