Estimating Quality of Life Decrements Due to Diabetes Complications in the United States: The Health Utility Index (HUI) Diabetes Complication Equation

Hui Shao, Shuang Yang, Vivian Fonseca, Charles Stoecker and Lizheng Shi ()
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Hui Shao: Tulane University
Shuang Yang: Tulane University
Vivian Fonseca: Tulane University
Lizheng Shi: Tulane University

PharmacoEconomics, 2019, vol. 37, issue 7, No 5, 929 pages

Abstract: Abstract Objective Health utility decrements associated with diabetes mellitus complications are essential for calculating quality-adjusted life-years (QALYs) in patients for use in economic evaluation of diabetes interventions. Previous studies mostly focused on assessing the impact of complications on health utility at event year based on cross-sectional data. This study aimed to separately estimate health utility decrements associated with current and previous diabetes complications. Research Design and Methods The Health Utilities Index Mark 3 (HUI-3) was used to measure heath utility in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 8713). Five macrovascular complications (myocardial infarction [MI], congestive heart failure [CHF], stroke, angina, and revascularization surgery [RS]) and three microvascular complications (nephropathy [renal failure], retinopathy [severe vision loss], and neuropathy [severe pressure sensation loss]) were included in a set of alternative modelling approaches including the ordinary least squares (OLS) model, fixed effects model, and random effects model to estimate the complication-related health utility decrements. Results All macrovascular complications were associated with decrements of HUI-3 scores: MI (event year: − 0.042, successive years: − 0.011), CHF (event year: − 0.089, successive years: − 0.041), stroke (event year: − 0.204, successive years: − 0.101), angina (event year: − 0.010, successive years: − 0.032), and revascularization (event year: − 0.038, successive years: − 0.016) (all p

Date: 2019
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DOI: 10.1007/s40273-019-00775-8

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