Estimating Age- and Sex-Specific Utility Values from the CHU9D Associated with Child and Adolescent BMI z-Score

Anagha Killedar (), Thomas Lung, Stavros Petrou, Armando Teixeira-Pinto and Alison Hayes
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Anagha Killedar: University of Sydney
Thomas Lung: University of Sydney
Stavros Petrou: University of Oxford
Armando Teixeira-Pinto: University of Sydney
Alison Hayes: University of Sydney

PharmacoEconomics, 2020, vol. 38, issue 4, No 5, 375-384

Abstract: Abstract Objective Our objective was to identify age- and sex-specific utilities for children and adolescents by body mass index (BMI) z-score. Methods We used data from 6822 participants and 12,094 observations from two cohorts and two waves of interviews from the Longitudinal Study of Australian Children. We fit linear models using generalised estimating equations to investigate associations between Child Health Utility 9D and BMI z-score in girls and boys aged 10–17 years. We initially fit models for each sex, fully adjusted for known predictors of health-related quality of life, including socioeconomic position, long-term medical condition and maternal smoking status and also included an interaction between age and BMI z-score to examine age-specific effects. Finally, we derived a minimal model for each sex by eliminating interaction terms with P > 0.01 and predictors with P > 0.05. Results Our adjusted results show different utility patterns in girls and boys. In girls, utility decrements for each unit increase in BMI z-score changed with age (P

Date: 2020
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DOI: 10.1007/s40273-019-00866-6

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