In a Child’s Shoes: Composite Time Trade-Off Valuations for EQ-5D-Y-3L with Different Proxy Perspectives

Stefan A. Lipman (), Brigitte A. B. Essers, Aureliano P. Finch, Ayesha Sajjad, Peep F. M. Stalmeier and Bram Roudijk
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Stefan A. Lipman: Erasmus University Rotterdam
Brigitte A. B. Essers: Maastricht University
Aureliano P. Finch: EuroQol Research Foundation
Ayesha Sajjad: Erasmus University Rotterdam
Peep F. M. Stalmeier: Radboud University Medical Center
Bram Roudijk: EuroQol Research Foundation

PharmacoEconomics, 2022, vol. 40, issue 2, No 8, 192 pages

Abstract: Abstract Background and Objectives EQ-5D-Y-3L health states are commonly valued by asking adults to complete stated preference tasks, ‘given their views about a 10-year-old child’ (hereafter referred to as proxy 1). The use of this perspective has been a source of debate. In this paper, we investigated an alternative proxy perspective: i.e. adults considered what they think a 10-year old-child would decide for itself (hereafter, proxy 2 (substitute)]. Our main objective was to explore how the outcomes, dispersion and response patterns of a composite time trade-off valuation differ between proxy 1 and proxy 2. Methods A team of four trained interviewers completed 402 composite time trade-off interviews following the EQ-5D-Y-3L protocol. Respondents were randomly allocated to value health states in either the proxy 1 or proxy 2 (substitute) perspective. Each respondent valued ten health states with the perspective they were assigned to, as well as one health state with the alternative perspective (33333). Results The use of different proxy perspectives yielded differences in EQ-5D-Y-3L valuation. For states in which children had considerable pain and were very worried, sad or unhappy, respondents’ valuations were lower in proxy 1 than in proxy 2 (substitute) perspectives, by about 0.2. Within-subject variation across health states was lower for proxy 2 (substitute) than proxy 1 perspectives. Analyses of response patterns suggest that data for proxy 2 (substitute) perspectives were less clustered. Conclusions There are systematic differences between composite time trade-off responses given by adults deciding for children and adults considering what children would want for themselves. In addition to warranting further qualitative exploration, such differences contribute to the ongoing normative discussion surrounding the source and perspective used for valuation of child and adolescent health.

Date: 2022
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DOI: 10.1007/s40273-022-01202-1

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