Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Corneliu Bolbocean, Sylvia Pal, Stef Buuren, Peter J. Anderson, Peter Bartmann, Nicole Baumann, Jeanie L. Y. Cheong, Brian A. Darlow, Lex W. Doyle, Kari Anne I. Evensen, John Horwood, Marit S. Indredavik, Samantha Johnson, Neil Marlow, Marina Mendonça, Yanyan Ni, Dieter Wolke, Lianne Woodward, Erik Verrips and Stavros Petrou
Additional contact information
Sylvia Pal: Netherlands Organisation for Applied Scientific Research
Stef Buuren: Netherlands Organisation for Applied Scientific Research
Peter J. Anderson: Monash University
Peter Bartmann: University Hospital Bonn, Children’s Hospital
Nicole Baumann: Monash University
Jeanie L. Y. Cheong: University of Melbourne
Brian A. Darlow: University of Otago Christchurch
Lex W. Doyle: University of Melbourne
Kari Anne I. Evensen: Norwegian University of Science and Technology
John Horwood: University of Otago Christchurch
Marit S. Indredavik: Norwegian University of Science and Technology
Samantha Johnson: University of Leicester
Neil Marlow: University College London
Marina Mendonça: University of Melbourne
Yanyan Ni: University of Melbourne
Dieter Wolke: University of Warwick and Division of Health Sciences
Lianne Woodward: University of Canterbury
Erik Verrips: Netherlands Organisation for Applied Scientific Research
Stavros Petrou: University of Oxford, Radcliffe Observatory Quarter

PharmacoEconomics, 2023, vol. 41, issue 1, No 8, 93-105

Abstract: Abstract Background and Objective Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.

Date: 2023
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DOI: 10.1007/s40273-022-01201-2

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