Estimating an EQ-5D-Y-3L Value Set for Brazil

Caique Melo Espirito Santo (), Gisela Cristiane Miyamoto (), Verônica Souza Santos (), Ângela Jornada Ben (), Aureliano Paolo Finch (), Bram Roudijk (), Fabianna Resende Jesus-Moraleida (), Airton Tetelbom Stein (), Marisa Santos () and Tiê Parma Yamato ()
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Caique Melo Espirito Santo: Universidade Cidade de São Paulo
Gisela Cristiane Miyamoto: Universidade Cidade de São Paulo
Verônica Souza Santos: Universidade Cidade de São Paulo
Ângela Jornada Ben: Vrije Universiteit Amsterdam
Aureliano Paolo Finch: EuroQol Research Foundation
Bram Roudijk: EuroQol Research Foundation
Fabianna Resende Jesus-Moraleida: Federal University of Ceará
Airton Tetelbom Stein: Federal University of Health Sciences of Porto Alegre
Marisa Santos: Instituto Nacional de Cardiologia
Tiê Parma Yamato: Universidade Cidade de São Paulo

PharmacoEconomics, 2024, vol. 42, issue 9, No 8, 1047-1063

Abstract: Abstract Introduction The EQ-5D-Y-3L is a generic measure of health-related quality of life in children and adolescents. Although the Brazilian-Portuguese EQ-5D-Y-3L version is available, there is no value set for it, hampering its use in economic evaluations. This study aimed to elicit a Brazilian EQ-5D-Y-3L value set based on preferences of the general adult population. Methods Two independent samples of adults participated in an online discrete choice experiment (DCE) survey and a composite time trade-off (cTTO) face-to-face interview. The framing was “considering your views for a 10-year-old child”. DCE data were analyzed using a mixed-logit model. The 243 DCE predicted values were mapped into the observed 28 cTTO values using linear and non-linear mapping approaches with and without intercept. Mapping approaches’ performance was assessed to estimate the most valid method to rescale DCE predicted values using the model fit (R2), Akaike Information Criteria (AIC), root mean squared error (RMSE), and mean absolute error (MAE). Results A representative sample of 1376 Brazilian adults participated (DCE, 1152; cTTO, 211). The linear mapping without intercept (R2 = 96%; AIC, − 44; RMSE, 0.0803; MAE, − 0.0479) outperformed the non-linear without intercept (R2 = 98%; AIC, − 63; RMSE, 0.1385; MAE, − 0.1320). Utilities ranged from 1 (full health) to − 0.0059 (the worst health state). Highest weights were assigned to having pain or discomfort (pain/discomfort), followed by walking about (mobility), looking after myself (self-care), doing usual activities (usual activities), and feeling worried, sad, or unhappy (anxiety/depression). Conclusion This study elicited the Brazilian EQ-5D-Y-3L value set using a mixed-logit DCE model with a power parameter based on a linear mapping without intercept, which can be used to estimate the quality-adjusted life-years for economic evaluations of health technologies targeting the Brazilian youth population.

Date: 2024
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DOI: 10.1007/s40273-024-01404-9

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