Developing an EQ-5D-5L Value Set for Singapore

Nan Luo (), Annushiah Vasan Thakumar, Ling Jie Cheng, Zhihao Yang, Kim Rand, Yin Bun Cheung and Julian Thumboo
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Nan Luo: National University of Singapore
Annushiah Vasan Thakumar: Taylor’s University
Ling Jie Cheng: National University of Singapore
Zhihao Yang: Guizhou Medical University
Kim Rand: Akershus University Hospital
Yin Bun Cheung: Duke-NUS Medical School
Julian Thumboo: Singapore General Hospital

PharmacoEconomics, 2025, vol. 43, issue 12, No 4, 1419-1431

Abstract: Abstract Objectives The EQ-5D-5L is a multi-attribute utility instrument recommended by many health technology assessment agencies. This study aimed to develop an EQ-5D-5L value set for Singapore. Methods A ‘lite’ version of the EuroQol Research Foundation’s EQ-5D-5L valuation protocol, which was designed to value a total of 91 health states using a composite time trade-off (cTTO) method, was followed. Five hundred members of the general public in Singapore were quota-sampled and invited to a personal interview face-to-face or via Zoom. All participants completed 20 cTTO tasks administered using the EuroQol Valuation Technology (EQ-VT) program. Cross-validation analysis was performed to identify the best-performing model for estimating the values of all the 3,125 EQ-5D-5L health states. Results A 20-parameter main-effects model with two two-way interaction terms outperformed other models in the cross-validation analysis. The value set estimated using this model ranges from − 0.851 (for state 55555) to 1.000 (for state 11111), with pain/discomfort and anxiety/depression dimensions associated with the greatest disutility. Conclusions We developed an EQ-5D-5L value set based on the health preferences of Singaporeans. We recommend EQ-5D-5L users in Singapore to use this value set and encourage a more systematic and dedicated methodological effort to understand interaction effects and potential non-linearities in the valuation of multi-attribute health descriptive systems.

Date: 2025
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DOI: 10.1007/s40273-025-01519-7

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