EQ-5D-5L or EQ-HWB-S: Which is the Better Instrument for Capturing Spillover Effects in Parental Carers of Children with COVID-19?

Wenjing Zhou, Bo Ding, Jan Busschbach, Michael Herdman, Zhihao Yang () and Yanming Lu ()
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Wenjing Zhou: Shanghai Jiaotong University
Bo Ding: Shanghai Jiaotong University
Jan Busschbach: Erasmus Medical Centre
Michael Herdman: National University of Singapore
Zhihao Yang: Guizhou Medical University
Yanming Lu: Shanghai Jiaotong University

PharmacoEconomics, 2025, vol. 43, issue 5, No 7, 555-567

Abstract: Abstract Background and Objectives ‘Caregiver health spillovers’ refer to the broader impacts of an individual’s illness and interventions on informal caregivers’ health and well-being. This study focuses on the spillover effects experienced by parental carers of children with coronavirus disease 2019 (COVID-19), aiming to compare the psychometric properties of the EQ-5D-5L and the experimental EQ Health and Wellbeing Short version (EQ-HWB-S) in capturing these effects. Methods A longitudinal study was conducted with 861 parental carers of children aged 0–18 years with COVID-19 and 231 parents of healthy children as the control group. The EQ-5D-5L and EQ-HWB-S were used to assess parental health and well-being. Analyses included known-groups validity (multivariable regression), test–retest reliability (Gwet’s AC1, intraclass correlation coefficient) and responsiveness to health improvement (Glass’ Δ effect size). Results Parents of infected children reported more problems than those of healthy controls. The EQ-HWB-S better discriminated between sub-groups defined by the child’s COVID-19 presence, caring time and work impact. Test–retest reliability was fair to good for EQ-HWB-S dimensions (Gwet’s AC1: 0.33–0.79), moderate to good for EQ-5D-5L (Gwet’s AC1: 0.40–0.76), and good for index scores and EQ VAS (intraclass correlation coefficient: 0.70–0.77). Parental health and well-being improved as children recovered, with the EQ-5D-5L showing slightly higher responsiveness (effect size: 0.77–0.87) than EQ-HWB-S (effect size: 0.62–0.74). Conclusions Both EQ-HWB-S and EQ-5D-5L are valid, reliable and responsive for measuring parental spillover effects related to a child’s COVID-19 infection. EQ-HWB-S outperformed in distinguishing social and emotional impacts of caregiving, while EQ-5D-5L better captured physical health improvements. The choice between tools may depend on study objectives.

Date: 2025
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DOI: 10.1007/s40273-025-01473-4

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