Associations between Health-Related Quality of Life and Self-Reported Emergency Room Department Visits and Inpatient Hospitalizations: Insights from a Secondary Data Analysis of Patients with Light-Chain (AL) Amyloidosis

Kristen L. McCausland (), Avery A. Rizio, Michelle K. White, Martha S. Bayliss and Tiffany P. Quock
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Kristen L. McCausland: Optum
Avery A. Rizio: Optum
Michelle K. White: Optum
Martha S. Bayliss: Optum
Tiffany P. Quock: Prothena Biosciences Inc

PharmacoEconomics - Open, 2019, vol. 3, issue 3, No 11, 367-375

Abstract: Abstract Introduction Light-chain (AL) amyloidosis is a rare, progressive, and typically fatal disease. Health-related quality of life (HRQoL) has been shown to be a significant prognostic factor associated with clinical outcomes such as survival and response to treatment. A better understanding of how patterns of HRQoL may be prospectively associated with costly healthcare resource utilization, such as emergency department (ED) visits and inpatient hospitalizations, is warranted. Methods A secondary data analysis of a non-interventional, longitudinal online study of patients with AL amyloidosis (n = 224) was conducted. Negative binomial regression models were used to examine whether initial HRQoL scores (as measured by the SF-36v2® Health Survey [SF-36v2], where higher scores reflect better HRQoL) and changes in HRQoL were associated with the number of ED visits and inpatient hospitalizations during a 12-month period. Incidence rate ratios were interpreted by 5-point decrements in initial HRQoL scores and minimally important changes in HRQoL change scores. Results There were significant inverse associations between initial SF-36v2 scores and subsequent rates of ED visits and inpatient hospitalizations across all domains and summary components (p

Date: 2019
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DOI: 10.1007/s41669-019-0122-7

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