A Multiple Stakeholder Multicriteria Decision Analysis in Diabetic Macular Edema Management: The MULTIDEX-EMD Study

Fernando de Andrés-Nogales (), Miguel Ángel Casado, José Luis Trillo, José María Ruiz-Moreno, José Manuel Martínez-Sesmero, Gemma Peralta, José Luis Poveda, Pere Ortiz, Emilio Ignacio, Javier Zarranz-Ventura, Patricia Udaondo, Carlos Mur, Eloísa Álvarez, Enrique Cervera, Mercedes Martínez, Iñaki Llorente, Jacinto Zulueta, Mariano Rodríguez-Maqueda, Alfredo García-Layana and José Martínez-Olmos
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Fernando de Andrés-Nogales: Pharmacoeconomics & Outcomes Research Iberia (PORIB)
Miguel Ángel Casado: Pharmacoeconomics & Outcomes Research Iberia (PORIB)
José Luis Trillo: Departamento de Salud Clínico Malvarrosa
José María Ruiz-Moreno: Universidad Castilla La Mancha, Albacete, Spain; Vissum Corporación, Spain; Hospital Universitario Puerta de Hierro Majadahonda
José Manuel Martínez-Sesmero: Hospital Clínico San Carlos
Gemma Peralta: Fundació Rossend Carrasco i Formiguera, MentBarcelona
José Luis Poveda: Hospital Universitari i Politècnic La Fe
Pere Ortiz: Consorci MAR Parc de Salut de Barcelona
Emilio Ignacio: Universidad de Cádiz
Javier Zarranz-Ventura: RETICS-OFTARED, Instituto de Salud Carlos III
Patricia Udaondo: Hospital Universitari i Politècnic La Fe
Carlos Mur: Hospital Universitario de Fuenlabrada
Eloísa Álvarez: Hospital Clínico San Carlos
Enrique Cervera: Hospital General Universitario de Valencia
Mercedes Martínez: Ministerio de Sanidad, Consumo y Bienestar Social
Iñaki Llorente: Hospital Universitario Nuestra Señora de la Candelaria
Jacinto Zulueta: Asociación Mácula Retina
Mariano Rodríguez-Maqueda: Hospital Universitario Virgen del Rocío
Alfredo García-Layana: RETICS-OFTARED, Instituto de Salud Carlos III
José Martínez-Olmos: Senado de España

PharmacoEconomics - Open, 2020, vol. 4, issue 4, No 7, 615-624

Abstract: Abstract Background The clinical and economic management of retinal diseases has become more complex following the introduction of new intravitreal treatments. Multicriteria decision analysis (MCDA) offers the potential to overcome the challenges associated with traditional decision-making tools. Objectives A MCDA to determine the most relevant criteria to decision-making in the management of diabetic macular edema (DME) based on the perspectives of multiple stakeholders in Spain was developed. This MCDA was termed the MULTIDEX-EMD study. Methods Nineteen stakeholders (7 physicians, 4 pharmacists, 5 health authorities and health management experts, 1 psychologist, and 2 patient representatives) participated in this three-phase project. In phase A, an advisory board defined all of the criteria that could influence DME treatment decision-making. These criteria were then screened using a discrete choice experiment (DCE) (phase B). Next, a multinomial logit model was fitted by applying the backward elimination algorithm (relevant criteria: p value

Date: 2020
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DOI: 10.1007/s41669-020-00201-2

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