Real-World Cost Effectiveness of a Policy of KRAS Testing to Inform Cetuximab or Panitumumab for Third-Line Therapy of Metastatic Colorectal Cancer in British Columbia, Canada

Reka E. Pataky (), Stirling Bryan, Mohsen Sadatsafavi, Stuart Peacock and Dean A. Regier
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Reka E. Pataky: Canadian Centre for Applied Research in Cancer Control, Cancer Control Research, BC Cancer
Stirling Bryan: University of British Columbia
Mohsen Sadatsafavi: University of British Columbia
Stuart Peacock: Canadian Centre for Applied Research in Cancer Control, Cancer Control Research, BC Cancer
Dean A. Regier: Canadian Centre for Applied Research in Cancer Control, Cancer Control Research, BC Cancer

PharmacoEconomics - Open, 2023, vol. 7, issue 6, No 11, 997-1006

Abstract: Abstract Background Cetuximab and panitumumab, two anti-EGFR therapies, are widely used for third-line therapy of metastatic colorectal cancer (mCRC) with wild-type KRAS, but there remains uncertainty around their cost effectiveness. The objective of this analysis was to conduct a real-world cost-effectiveness analysis of the policy change introducing KRAS testing and third-line anti-EGFR therapy mCRC in British Columbia (BC), Canada. Methods We conducted secondary analysis of administrative data for a cohort of mCRC patients treated in BC in 2006–2015. Patients potentially eligible for KRAS testing and third-line therapy after the policy change (July 2009) were matched 2:1 to pre-policy patients using genetic matching on propensity score and baseline covariates. Costs and survival time were calculated over an 8-year time horizon, with bootstrapping to characterize uncertainty around endpoints. Cost effectiveness was expressed using incremental cost-effectiveness ratios (ICER) and the probability of cost effectiveness at a range of thresholds. Results The cohort included 1757 mCRC patients (n = 456 pre-policy and n = 1304 post-policy; of those, n = 420 received cetuximab or panitumumab). There was a significant increase in survival and cost following the policy change. Adoption of KRAS testing and anti-EGFR therapy had an ICER of CA$73,759 per life-year gained (LYG) (95% CI 46,133–186,446). In scenario analysis, a reduction in cetuximab and panitumumab cost of at least 50% was required to make the policy change cost effective at a threshold of CA$50,000/LYG. Conclusion A policy of third-line anti-EGFR therapy informed by KRAS testing may be considered cost effective at thresholds above CA$70,000/LYG. Reduction in drug costs, through price discounts or potential future biosimilars, would make anti-EGFR therapy considerably more cost effective. By using real-world data for a large cohort with long follow-up we can assess the value of a policy of KRAS testing and anti-EGFR therapy achieved in practice.

Date: 2023
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DOI: 10.1007/s41669-023-00444-9

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